Kyan Anderson scored a game high 23 points, good for his 18th 20+ point effort in his career, as the Horned Frogs cruised to a 74-50 victory in the second half over Radford.
Hudson Price scored 14 points on 5-7 shooting, including 2-2 from deep.
The win moves TCU's record to 5-0 for the first time since the 1997-98 season, when the Frogs started off the year 9-0. Kaviar Shepherd, Trey Zeigler and Kenrich Williams all collected six rebounds for the Frogs, who outrebounded Radford 39-34.
The Frogs started slowly in the first half, allowing Radford to hang around for the majority of the first half, but a late spark from Anderson gave TCU a 31-20 lead at halftime.
They came out on fire in the second half, pulling ahead by as many as 30 before pulling off the gas and cruising to a 24 point win.
The Frogs will head to Corpus Christi to play in the Corpus Christi Coastal Classic, where they'll face off against Bradley on Friday, and the winner of St. Louis vs. Mississippi State on Saturday.